Think Like a Doctor: Sweating It Out
By LISA SANDERS, M.D. from New York TimesThe Challenge: Can you solve a medical mystery involving a 25-year-old man who gets sweaty and nauseated and starts vomiting uncontrollably every few weeks? The hot shower had seemed to work, leaving him feeling remarkably good, with no nausea, and none of the dread that seemed to come with it.
New York Times這期考讀者們,一位年輕人每數週就一直猛流汗,吐,想要一直沖澡,這是什麼原因呢?我會提出來不只是對答案有興趣,更對發現這答案的過程有興趣,所以和大家分享。
The correct diagnosis is…
Cannabinoid hyperemesis caused by smoking synthetic marijuana.
發現的過程
在2004年,Dr. James H. Allen,澳洲的內科醫師,對一位被認為是精神病引發的嚴重嘔吐患者感到興趣(a syndrome of nausea and vomiting, compulsive bathing and chronic marijuana use. ),此外這位患者住院時一直在淋浴。這患者的症狀,在住院後,不用處置,也會自然改善,但一回到家就再發作。他也注意到這患者是 chronic heavy marijuana user,因為推測這些症狀是marijuana引起的(當時沒有人了解)。
幾年後,他把手上的10多位同類患者,發表成論文(Gut 2004;53:1566-1570. Stomach. Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse)
A Marijuana Syndrome, Without the Marijuana:
Dr. Allen的報告引起全球的注意,然而marijuana過往是認為有些止吐的效果,怎麼在慢性使用者身上引起了嚴重的嘔吐,原因尚不明,也許是因為marijuana內含有多種複合物,許多的交互作用所致。另外,除了天然的marijuana,也有合成的(synthetic marijuana),起初科學家是希望能在它身上找到新的止痛成份,但是太難純化,而放棄了,但是,這合成的marijuana仍在美國可以買到,所以,才有以上這個故事。
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