生活型態改變可以減輕基因導致的冠心症危險性

The “nature versus nurture”, which is more important?

美國心臟醫學會上的Breaking News，這篇文章真是令人覺得勵志，因為可以經由後天的生活形態改變，減輕因為基因導致的冠心症危險性。

對象是來自三個不同的大型研究（Women's Genome Health Study，Atherosclerosis Risk in Communities，Malmö Diet and Cancer Study），共51,425 個病人，找出和CAD有相關性的危險基因（polygenic scores of single nucleotide polymorphisms associated with CAD)

那一些生活形態呢？1) no current smoking 2) no obesity 3) regular physical activity 4) healthy diet.

結果發現，有較高冠心症危險基因者，若是有3個以上「好」的生活習慣，比有一個「壞」的習慣，下降了接近一半(46%)冠心症的風險。

For individuals at high genetic risk, unhealthy and healthy lifestyles were associated with the following standardized 10-year incidences of coronary events:

Women's Genome Health Study, 4.6% and 2.0%

Atherosclerosis Risk in Communities, 10.7% and 5.1%

Malmö Diet and Cancer Study, 8.2% and 5.3%

所以作者的結論是：
We need to get the message to our patients: A healthy lifestyle can mitigate one's inherited cardiac risk.

Ref.
Khera AV et al. Genetic risk, adherence to a healthy lifestyle, and coronary disease. N Engl J Med 2016 Nov 13; [e-pub]. (http://dx.doi.org/10.1056/NEJMoa1605086)